Endocrine Abstracts

Repeated pregnancy loss (RPL), defined as two or more spontaneous abortions, may be associated with autoimmune thyroiditis (AT), either isolated or associated with polyautoimmune disorders (PD), which include antiphospholipid syndrome. An increased occurrence of RPL has been reported in patients with isolated AT but very few data are available on the influence of concurrent auto-aggressive disorders on RPL and this represented the aim of our study. A cohort of 1765 consecutive...

Objective: Intestinal barrier (IB) is one of the wider human body surface, whose integrity allows the uptake of nutrients also preserving from the entrance of harmful compounds. An increased permeability of IB, known as “leaky gut”, has been demonstrated in patients with intestinal inflammatory and/or autoimmune disorders as well as in patients with autoimmune diseases involving organs far from the intestine, as in patients with Hashimoto’s thyroiditis (HT). The...

Objectives: Human CD3+CD20+ T cells represents 3-5% of circulating T cells and may be detected in all lymphatic organs and in the cerebrospinal fluid. In healthy individuals CD3+CD20+ T cells have been shown to produce higher levels of IL-17A and/or IFN-γ than those of CD3+CD20- T cells. Some reports described the role of CD3+CD20+ T cells in autoimmune disorders such as multiple scler...

Background: The association of autoimmune thyroiditis (AIT) with nonendocrine autoimmune disorders has been reputed for long time as a variant of type 2 polyglandular autoimmune syndrome (PAS2). Nowadays, it is framed in the picture of polyautoimmunity and its relevance is owed to its prevalence, far higher than PAS 2, and its expanding galaxy. Systematic studies on this field are rather scanty and mostly based only on the presence of circulating antibodies. Our study has been...